Summary
Our real world can logically never truly intersect with fictional worlds. The fact that people have created a fiction in our view just means that they have created, for example, words and pictures. The authors have not created any new realities, they have not created intelligent and spiritual beings. They have just created stories within books, comics, games, TV, movies, or animation. We compare the fictional worlds from their points of view. And to them our world does not exist in any sense.
Author avatars and significant 4th wall breaking instances should be evaluated on a case-by-case basis, as not all of them are equal in merit and significance. Likewise, a few general rules of thumb should be adhered to:
Firstly, no matter what the author's intentions are, fiction and reality can never fully interact. The real world, and real people can be simulated within fiction, but they will still be fictional representations and characters. As such, no fictional character can be responsible for the creation of "The real world".
Secondly, Author Avatars are not inherently bad, as some fictions use them in meaningful and relevant manners. There are several games in which the player is a part of the story proper, as well as numerous stories in which the author is made present, either through an avatar or fictionalized portrayal. We have to see if the author avatar is relevant, or if it is just a wink towards the audience.
Thirdly, Author Avatars do not equate tier 0 boundlessness, and characters beating/killing their authors are not quantifiable nor meaningful feats. For instance, while The Lord of Nightmares beat her writer with a shovel, said "writer" was still a fictional character, and in no way, shape or form can LoN affect real people, or actually defeat her real world writer. Similarly, no one should look at real life humans as a "tier 0 species", simply because we can write stories.